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L -acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

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The nitrogen from one amino acid thus appears in another amino acid one of the -keto acid / -amino acid pairs is always -ketoglutarate / glutamate EXAMPLE: the amino acid aspartate can be transaminated to form its cognate -keto acid oxaloacetate

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492 These findings suggest that hyperglycemia is only one of multiple factors contributing to neuropathy in T2DM, highlighting the need for a multifactorial approach to management