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Yanai H, Adachi H, Hakoshima M, Katsuyama H (2024) Pathology and Treatments of Alzheimers Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes

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Once synthesized, melanin is contained in special organelles called melanosomes which can be transported to nearby keratinocytes to induce pigmentation

Specifically, changing the Val229 residue to alanine, selected in this study for further investigation, was predicted to trigger a change in the cavity and a buried exposure switch at the inactive receptor, thereby potentially modifying the interactions between itself and other pocket residues with cholesterol