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A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS treated with metformin reported that the total testosterone and androstenedione decreased to 15.4 47.9% and 11.3 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 61.8 and 24.8 40.5% at the fifth year of the follow-up (22)

Older weight-loss drugs tended to shave off only a few percentage points of body weight, and they came with tough trade-offs and quick weight rebound

So it's very long and they go through all of the different factors that affect holiday weight gain and they talk about the stats of it