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However, in a retrospective study of 559 patients with nonsmall cell lung cancer (NSCLC) given nivolumab or pembrolizumab, 231 (41%) developed irAEs, and 40 (17.4%) presented multiple-site irAEs

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Patients had a mean age of 61 years and 54% were men

The breakthrough insight was recognizing that glucagons thermogenic properties could be harnessed without destabilizing blood sugar when paired with the glucose-lowering effects of GLP-1 and GIP activation

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