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Huang D, Shang W, Xu M, Wan Q, Zhang J, Tang X, Shen Y, Wang Y, Yu Y

demonstrated that the reduction in oxidative stress induced by metformin (dose: 1 mM) is associated with the downregulation of NADPH Oxidase 4 (NOX4) expression

Crucially, the side effect profile of NAD+ largely depends on dosage and infusion rate

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