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8 Another 2023 meta-analysis among 93 studies comparing GLP-1 RAs to placebo, insulin, or oral antidiabetic medicine found GLP-1RA use was associated with increased risk of both early and late-stage DR, although these results barely reached statistical significance with 95% confidence intervals of 1.01 to 1.68 and 1.01 to 1.66, respectively

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It has been demonstrated that young subjects with PWS engaged in less overall physical activity than subjects with obesity without PWS, on both weekends and throughout the week [26]