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When the concentration of L-arginine or BH4 is low, or BH4 becomes oxidized under conditions of oxidative stress, there is increased endothelial dysfunction because vasoconstriction increases and vasodilation decreases, contributing to increased pressure within the vessels (91)

Serra E, Puig S, Otero D, Gaona A, Kruyer H, Ars E, et al

These data support further evaluation of cotadutide in NASH treatment

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The muscle simply feels heavier, thicker, and harder to the touch continuously, rather than just retaining water or glycogen