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The ASCO GI 2026 data suggest that GLP-1 therapy may be particularly relevant for metabolically high-risk populations, including individuals with obesity, insulin resistance, or type 2 diabetesgroups that now account for a substantial proportion of colorectal cancer burden

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This is significant because of a phenomenon known as the "entourage effect." The entourage effect is the theory that all these compounds work together synergistically to enhance the potential benefits of the plant