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Key exclusion criteria were any clinically significant concomitant disease or disorder, clinically significant abnormal values in clinical laboratory screening tests, any history of gastrointestinal surgery (except uncomplicated surgical procedures), or current smokers smoking more than five cigarettes (or equivalent) per day

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In healthy volunteers ( N = 54), administration of a proton pump inhibitor, omeprazole (40 mg once daily), resulted in a slight non-statistically significant increase in exposure to semaglutide that was not considered to be clinically relevant and no dose adjustment is recommended with these agents [34]

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