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Tirzepatide vs Retatrutide Tirzepatide is a dual agonist, engaging GLP-1 and GIP

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It is unlikely to reach the cytosolic site where 5-alpha reductase converts testosterone to DHT, and it does not bind that enzyme through any documented mechanism

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Consistent with this, AI-based structural prediction 74 indicated a direct interaction between NHR-49 and XPO-1 that required its small GTPase cofactor RAN-1 (ipTM = 0.66 versus 0.54 without RAN-1) (Fig

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