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We reproduced this potentially reversible response by human adult mature OLs in both dissociated cell culture and microfibre ensheathment assays, using an array of insults implicated in MS pathogenesis including the pro-inflammatory molecules interferon (IFN)- and tumor necrosis factor (TNF)-, the excitatory neutrotransmitter glutamate, and metabolic stress conditions involving nutrient deprivation and low glucose 19,42

If additional trials confirm that they effectively curb cravings across addictive substances, these drugs could begin to close one of the most consequential treatment gaps in medicine

Treatment frequency depends on your individual needs and should be discussed during your consultation

GLP-1 drugs reduced kidney failure by 16% and major heart events by 13% across all studies.5 THE BOTTOM LINE GLP-1 medications are now considered a fourth pillar of kidney protection for people with type 2 diabetes, alongside blood pressure drugs, SGLT2 inhibitors, and finerenone

Pochini et al., 2019