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It acts directly on the hypothalamus to stimulate the release of gonadotropin-releasing hormone (GnRH), which in turn triggers the pituitary gland to secrete LH and FSH

Thus, they are supported by stringent Federal Drug Administration (FDA) guidelines ensuring their efficacy and safety [87]

Typical administration is one to two metered sprays per nostril, once or twice daily

10.1016/j.ymgme.2007.10.006 50 JiangZ.KnudsenN

Electrostatic potentials for ScGrx6 and ScGrx7 were computed and mapped to the protein surface using the PoissonBoltzmann method of Swiss-PDB Viewer (dielectric constant solvent: 80, atomic partial charges, dielectric constant protein: 4, solvent ionic strength: 0.1 M)