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clinical studies in CKD patients show vitamin E supplementation reduces erythrocyte lipid peroxidation and enhances deformability, complementing EPO therapy to alleviate renal anemia (Gkkuu and Mostafazadeh, 2003

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At six months, glutathione levels increased 30 to 35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal cells in the high-dose group

Redox Signal 2017 Giardini, V et col

Endothelial dysfunction and cardiovascular disease The maintenance of a healthy endothelium is of utmost importance in the regulation of various cardiovascular functions, including but not limited to blood flow and fibrinolysis, hemostasis, vascular tone, angiogenesis, monocyte/leukocyte adhesion, and platelet aggregation