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PINK1 silencing upregulated the mitochondrial biogenesis regulators PGC-1 and mtTFA protein expression, concomitant with a significant increase in mtDNA copy number

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Biochem Biophys Res Commun 495:4652 Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA (2016) The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Supplementation is typically only necessary in cases of intense physical stress or certain medical conditions

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