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The manufacturer (Novo Nordisk) specifies that unopened pens must be refrigerated, while in-use pens may be kept at room temperature (not exceeding 30C) for up to 6 weeks

Blood glucose levels, HbA1c levels, weight changes, and any adverse reactions should be closely monitored

Gabby tried a variety of weight loss methods, without results

Conclusion: First line use of SGLT2i and GLP-1RAs is effective in reducing HbA1c, weight, and FPG levels in T2DM patients at low risk for cardiovascular disease

These findings suggest that previously documented alpha-cell heterogeneity within the exocytic capacity (63) and Ca 2+ responses to glucose (64, 65) may extend to proglucagon processing