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Patients with neurodegenerative diseases such as Parkinson disease and Alzheimer disease exhibit altered gut microbiota during the preclinical stages (Schneider et al., 2024), suggesting that gut dysbiosis may be an early event in the pathogenesis of neuropsychiatric disorders

While the high sensitivity suggests that GDF15 may be helpful for screening purposes, the relatively low specificity limits its potential as a standalone diagnostic biomarker

Treatment plans may be adjusted only by the provider

Adipose tissue is divided into WAT with a small number of mitochondria in the cell and BAT with a large number of mitochondria in the cell

23 Obstructive sleep apnea (OSA) is also very common in HFpEF patients because it worsens cardiac function by increasing sympathetic tone and leading to chronic hypertension and eventually left ventricular stiffness