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The limitation is indirect delivery

doi: 10.3390/ijms24021523 128 ShangJTangGYangJLuMWangCZWangC

In addition to its recognition of the UGA codon (162, 210), the tRNA sec is unique in that it becomes aminoacylated with Ser, which is then enzymatically converted to Sec by Sec synthase using selenophosphate as a selenium donor

Patients should take extra precaution to avoid any factors that can cause oxidative stress

144 Based on estimates, under physiological conditions, one-third of the HSA exists as disulfides mixed with cysteine, homocysteine, or glutathione (HSA-S-S-R), whereas the rest of the HSA is in a reduced form with a free thiol in the Cys-34 residue (HSA-SH)