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This reduces gastric distension and works better with the medication's effect on gastric emptying

Naltrexone is known to frequently cause stomach side effects like nausea and vomiting, stomach pain or cramping, and loss of appetite which could contribute to weight loss

Efficacy of tirzepatide for weight loss and it's comparative effectiveness to weight loss surgery in inflammatory bowel disease

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There was an average weight loss of 5.7% in the liraglutide group compared to placebo (average weight loss of 1.6%), along with a 3.4-mmHg decrease in systolic blood pressure [110]