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The receptor selectivity difference matters clinically because GIP activation independently promotes satiety, reduces appetite-driven eating, and may enhance energy expenditure through brown adipose tissue activation

Of subcutaneous semaglutide users, 9% to 11% decided to stop treatment due to adverse effects

Volonakis, S

'No other drug has come close to producing this level of weight loss this really is a game changer,' said lead author of the study, Professor Rachel Batterham from UCLs Centre for Obesity Research