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This stabilized form resists gastric acids to enable oral bioavailability while maintaining the therapeutic function of the original peptide [9]

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However, in insulin resistance, the cells become less responsive to insulins actions, leading to increased levels of glucose in the blood.The pathophysiology of insulin resistance is complex and involves multiple mechanisms

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Genetic Factors and Individual Metabolic Response: When to Seek Personalization Genetic variation in glucose regulation genes (e.g., FTO rs9939609) and appetite-pathway genes (e.g., MC4R rs17782313) influence baseline metabolic efficiency and satiety signaling