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Smooths and protects hair: Keratin forms a protective layer around hair strands, smoothing the cuticle and reducing frizz

Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice

In the present study, PRP was not exogenously activated before injection

Probiotic evidence is stronger but concentrated in specific groups such as critically ill children (Kumar et al., 2013, PMID 23361033)

At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / green tea extract (GTE), standardized to EGCG (epigallocatechin gallate) Primary concern / additive hepatotoxicity at GTE doses 400 mg EGCG/day Secondary concern / CYP1A2 and CYP3A4 modulation may shift isotretinoin metabolism Dietary green tea risk / low, typical brewed cup contains 50 to 100 mg EGCG Monitoring required / LFTs (ALT, AST) at baseline and weeks 4, 8 per iPLEDGE protocol FDA DILI signal / GTE linked to drug-induced liver injury in 29 case reports reviewed by NIH LiverTox Recommendation / avoid concentrated GTE supplements during isotretinoin