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10.1016/s0021-9258(17)45391-9 32 EngelM

It also acts on appetite/satiety centres, contributing to reduced food intake

"While novel immunotherapies allow for life-extending therapy for selected forms of cancer, their success is associated with potentially substantial toxicity

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Furthermore HLA-DR expression is reduced in the peripheral blood DCs of elderly subjects, which leads to diminished antigen presentation and contributes to the age-related decline in immune responsiveness [256]