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Feelings of sadness, irritability, and anxiety are common as the body adjusts to the absence of substances

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Additionally, specific-purpose antioxidants introduced as potential treatment coadjutants, SOD (EUK-134) and CAT (manganese porphyrins) mimics demonstrated efficacy in animal models of diabetic nephropathy and resistant HTN opening the door to future human trials (Wilcox and Aslam, 2021)