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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation
However, 1.2-1.5 grams per kilogram (divide your weight by 2.2) is more ideal for those who are physically active and what they typically are recommending for individuals on GLP-1 meds
These notable side effects can deter people from conforming to treatment plans
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Nature DOI:10.1038/s41586-026-10444-4 Abstract A brain reward circuit inhibited by next-generation weight-loss drugs in mice Glucagon-like peptide 1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes
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