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In people with lower starting weights, small doses could have big impacts, he says

The same trials are also the only window onto long-term safety: what are the implications of the elevated resting heart-rate in patients with heart failure or irregular heartbeats, let alone healthy individuals considering the longer term health implications of these drugs

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They can load various antioxidants with water and lipid solubility, and are biocompatible and biodegradable, reducing toxicity in clinical use