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By means of the EPR effect, nanovehicles of suitable sizes can penetrate by the endothelial cells interval into synovial, where they are sequestered for sustained drug discharge

J Alzheimers Dis (2015) 45(3):82335

[21] Glucagon also decreases fatty acid synthesis in adipose tissue and the liver, as well as promoting lipolysis in these tissues, which causes them to release fatty acids into circulation where they can be catabolised to generate energy in tissues such as skeletal muscle when required