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OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

By mediating cystine uptake, SLC7A11 governs rate-limiting GSH production

Grafts were sterilized with ethylene oxide to ensure aseptic conditions

Our APAP model [10] is simple because it does not include the processing of GSH in the mitochondria that has been shown to be fundamental for liver cell death in the presence of APAP [36]

Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats