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The half-life row deserves care: both are long-acting once-weekly agents, but they get there differently CagriSema combines two separately long-acting peptides, while tirzepatide is one molecule engineered for slow clearance

And throughout, only use sterile technique, carefully calculate doses, and be willing to stop altogether at the first sign of unusual side effectsespecially changes in nevi or new pigmented lesions

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Current recommendations from the American Society for Metabolic and Bariatric Surgery and the Endocrine Society support considering these agents as part of comprehensive management when lifestyle modifications prove insufficient and specific clinical criteria are met