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ZnT2 is critical for TLR4-mediated cytokine expression in colonocytes and modulates mucosal inflammation in mice

It also helps regulate homocysteine levels, which is important for cardiovascular health

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There is a considerable suggestion that physical and psychological stressors play a central part in the beginning as well as infection of gastrointestinal disorders to affect potential intermediaries like cytokines corticotropin-releasing hormone, and thyrotropin-releasing hormone

ER stress is known to be implicated in the pathology of many inflammatory disease models, including LPS-induced lung inflammation (Kim et al., 2013), high-fat diet-induced insulin resistance (Yuzefovych et al., 2013), or chronic graft-versus-host disease (Mukai et al., 2017)