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Higher doses are often required to achieve higher CNS exposure, which in turn increases the risk of systemic toxicity

J., Brodersen K

Despite the fact that peptide ligands are relatively flexible and have a lower binding affinity to receptors compared with antibodies, the use of peptides in theranostic nanomedicine offers advantages because they are smaller, have reduced immunogenicity, have high multivalency, penetrate deep into tumors, are simpler to synthesize, and are cost-effective in production

These findings could enable the study of arterial stiffness in large clinical trials and population studies

FDA sorts nominated bulk substances into categories while it works through the review process: Category 1 under evaluation