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2225 Studies tested vitamin B 12 supplementation to alleviate some of the symptoms of various diseases that are also present in COVID-19 (Table 2)

O-GlcNAc-modified NOS1 adapter (NOS1AP) exerts a protective effect against glutamate-induced neuronal apoptosis because of the decreased interaction between NOS1AP and neuronal nNOS [120]

Mammalian alpha beta hydrolase domain (ABHD) proteins: lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

Patients with genetic variants associated with reduced B12 absorption or increased metabolic demand often benefit most from methylcobalamin (more bioavailable) or intramuscular administration, rather than standard oral cyanocobalamin

Safety and Side Effects: Most side effects are mild and temporary