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A 2025 clinical update confirmed that B12 supplementation, including injections, does not improve energy or cognitive performance in non-deficient individuals

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In addition to the reduced glutathione (GSH)/GPX4 axis, ferroptosis is inhibited by the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q10 (CoQ10), GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)/CoQH2 pathways [162]

PLoS One 10 , e0142314 (2015)