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A randomized controlled trial published in PMC demonstrates that older humans (71.1 years) exhibited significantly lower glutathione levels, impaired mitochondrial fatty-acid oxidation, reduced gait speed and physical function, and higher oxidative stress compared to young controls (25.5 years)

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The robust fluorescent signal detected in MSC2 cells encouraged evaluation of this assay for the detection of peroxynitrite in mouse models of cancer as well as human cancer patients where MDSC expression was expanded