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10.3390/ijms251910853 202 YiH.YuH.WangL.WangY.OuyangC.KeshtaB

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STEP 4 used a 20-week open-label run-in before randomization, and participants achieved a mean weight reduction of 10.6% across that run-in period

Study outcomes In this large, population-based retrospective cohort study, our primary outcome was to assess the incidence or new-onset of major adverse cardiovascular events categorized as HF, composite cardiovascular events 23,24 , as well as clinically significant portal hypertension events 25