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28 However, small molecules also face a higher risk of 9-year IRA negotiations, leading to a strategic tension between ease of administration and longevity of premium pricing

For constipation management, increasing soluble fibre gradually (such as ispaghula/psyllium) is recommended by NICE guidance for IBS, while excessive insoluble fibre should generally be avoided as it may worsen symptoms

But MDLs aren't perfect

Beneficiaries who are placed on the PMP by their TRICARE Managed Care Support Contractor are required to obtain controlled medication from one provider

Endocrine-disrupting chemicals: an endocrine society scientific statement