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Prior studies have shown GLP-1 analogs inhibit AgRP neurons in slice preparations and modulate Agrp gene expression (21, 44), but they did not demonstrate an acute in vivo effect of peripherally administered GLP-1R agonist on AgRP neuron dynamics

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Indias weightloss drug sales have grown tenfold in five years to US$153 million (S$195 million) as of 2026, and are projected to soar to over half a billion by 2030

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