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In animal studies, Semaglutide demonstrated neuroprotective and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein regulating the innate immune system and inflammatory responses

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Regulation of type 1 IP(3) receptor expression by dopamine D2-like receptors via AP-1 and NFATc4 activation

The findings presented here unveil previously unrecognized roles of PDK1 neddylation and offer a potential strategy for targeting the PI3KAkt pathway and KRAS mutant cancer therapy

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