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Qin Zhang, [email protected] These authors have contributed equally to the work This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)

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