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In addition, pharmacovigilance studies have reported signals of neuropsychiatric adverse events associated with GLP-1 receptor agonists, particularly in vulnerable populations such as individuals with prior psychiatric disorders or rapid weight loss [17, 53,54,55]

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The infrastructure is now being built: the CMS-0057-F rule mandates FHIR-based PA APIs by January 2027, AHIP pledges are driving operational improvements since January 2026, and the Medicare GLP-1 Bridge demonstration starting July 2026 will test centralized electronic PA at unprecedented scale