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Particular emphasis is placed on rational design principles that consistently enhance brain bioavailability and therapeutic efficacy across models of Alzheimers disease, Parkinsons disease, multiple sclerosis, and related disorders

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

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doi: 10.3389/fncel.2022.985943 Received 04 July 2022 Accepted 20 October 2022 Published 10 November 2022 Volume 16 - 2022 Edited by Silvia Snchez-Ramn, Complutense University of Madrid, Spain Reviewed by Jorge Matias-Guiu, Complutense University of Madrid, Spain

Iranian Journal of Basic Medical Sciences, 25 (10), 1166-1176