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415 Antidepressants target astrocytes Antidepressant drugs include (i) selective serotonin reuptake inhibitors (SSRI), of which fluoxetine (Prozac) is the most popular, (ii) serotonin/noradrenaline reuptake inhibitors (SNRI), (iii) tricyclic antidepressants, (iv) inhibitors of monoaminoxidase, (v) lithium, and (vi) ketamine

Amylin Receptor Activation Cagrilintide mimics native amlyin, binds to amlyin receptor predominantly in the postrema area and regions of brain with appetite regulation

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We show that this mitochondrial plasticity is driven by a need to resolve nucleotide stress via ATP-consuming UCK2