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Morphologically, ferroptosis is characterized by necrotic-like features, including loss of mitochondrial cristae, increased membrane density, outer membrane rupture, and reduced mitochondrial volume, while preserving plasma membrane integrity during early stages and maintaining normal nuclear morphology
Inhibition of CYP450 enzyme activity and activation of the Nrf2 signaling pathway and GSH synthesis are two intriguing targets for the treatment of acute liver injury caused by APAP
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