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The dysregulated immune response in chronic wounds is a consequence of an imbalance between pro-inflammatory and anti-inflammatory signals

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pagophagia is so specific to iron deficiency it is considered diagnostic Sore or smooth tongue (atrophic glossitis), cracks at the corners of the mouth (angular cheilitis) Mood changes anxiety, low mood, irritability tied to disrupted dopamine synthesis Heart palpitations or a racing pulse If you are losing more hair than usual, fatigued despite sleeping well, or notice ice cravings, run a ferritin test before assuming the cause is something else

These events usually improved or resolved, but they led to treatment discontinuation in a small number of participants

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