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The contribution of the rotation around dihedral angles to the potential energy was calculated using the following equation: where k is the torsion barrier (rotation barrier), k is the current value of the torsion angle, n is the period (the number of energy minima per one full cycle), and 0 is the standard value of the torsion angle

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This lowered the head in relation to the body, which maximized the surface area of the olfactory epithelium for efficient dosage uptake [8]

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