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Melatonin is responsible for increasing the expression of the mediator that interacts with Bcl-2 (Bim), activating the transcription of the FoxO3a factor, and increasing its concentration in the nucleus [30]

Moreover, ROS may affect the activity of histone regulators such as histone deacetylases or DNA methyltransferases known to oxidise the guanine residues

The participation of folate can ensure the normal synthesis of hemoglobin, thereby enhance the oxygen-carrying capacity of red blood cells and prevent the aggravation of anemia symptoms due to an insufficient hemoglobin content

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Alkylsquarates as a key intermediates for the rapid preparation of original drug-inspired compounds