once-weekly semaglutide in adults with alcohol use disorder RCT: reduces craving and consumption - Knopf - 2025 - Alcoholism & Drug Abuse Weekly A new clinical trial supported

Given several lines of evidence for GLP-1 resistance (elevated GLP-1 levels in the absence of a biological effect on glycemia or GE), we analyzed transcript expression of the GLP-1 receptor ( Glp1r ) and monitored GLP-1 receptor signaling by measuring cAMP levels following administration of Exendin-4 in the gastric pylorus, which influences GE rate

These changes result in an overall amplification of intracellular estrogen bioavailability and support a mechanism by which local concentrations of estrogen can change quickly following acute stress or damage (Pomari et al., 2015)

Fazio S, Linton MF

The Brain Peptide With the Most Human Data Is the One Nobody Hypes In 2012, a university press release called a new peptide the most powerful cognitive enhancer ever discovered

CBT-Is increasing acceptance marks a significant departure from how insomnia used to be perceived and treated