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In an exploratory analysis, tirzepatide was associated with reduced glucose variability (mean amplitude of glycemic excursion estimated treatment difference 16.5 [95% CI 31.6 to 1.4]

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For example, chemogenetic inhibition of VTA dopamine neurons prevented the ability of a priming injection of cocaine and stress to reinstate drug seeking in cocaine-experienced rats 59

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Cost and insurance coverage are major barriers: these drugs are expensive, branded biologics, and many insurers impose strict criteria (e.g., documented failure of lifestyle therapy, presence of comorbidities, high BMI thresholds) before approval