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Maintenance schedule Month 1-2 : Stay at current dose, assess stability Month 3-4 : Reduce by 2.5mg, monitor weight Month 5-6 : Reduce again if weight stable Long-term : Minimum dose that prevents regain Coming off tirzepatide Not recommended : Abruptly stopping often leads to rapid weight regain
The randomised, double-blind, placebo-controlled trial enrolled adults with type 2 diabetes managed with diet and exercise alone or with stable oral antidiabetic therapy (excluding sulphonylureas and insulin in most arms)
In the present study, autophagy was induced by high glucose concentrations, as directly observed by the accumulation of autophagic vacuoles in the cytoplasm, as well as by the increase in the content of the autophagic markers, LC3-II and Beclin1
doi: 10.3390/plants10020194 32 do NascimentoC