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Reach for Caya instead of wondering whether your pill actually stayed down

Kirkland, New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

The human GLP-1R was modified with its native signal sequence (M1-P23) replaced by the HA signal peptide to facilitate receptor expression

While same mitochondrial problems are present in the UMNs of ALS patients with TDP-43 pathology and UMNs of TDP-43 mouse models, and since pathologies are shared at a cellular level, regardless of species, we first analyzed the metabolite profile of both healthy and diseased motor cortex to investigate whether metabolomic changes occur with respect to TDP-43 pathology

These results were published in The Lancet