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The receptor-selectivity profile traces back to the two non-coded residues (-aminoisobutyric acid at position 1 and D-2-naphthylalanine at position 3) and the D-phenylalanine at position 4

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Astrocytes induce apoptosis by secreting TNF-, IL-1, and excess Glu, which activate neuronal TNFR1 or cause Ca 2+ overload, triggering extrinsic (caspase-8/-3) and intrinsic (Cyt C release) apoptosis [251]